International Union for Circumpolar Health Ministry of Public Health and Social Development of RF Russian Academy of Medical Sciences Siberian Branch of Russian Academy of Medical Sciences Siberian Branch of Russian Academy of Sciences Medical Polar Fund “Science” The Northern Forum

Abstracts

Cardiovascular diseases

Aim. To define the incidence of homocysteinemia (HHcy) and the role that HHcy plays in the pathogenesis of vascular complications due to type 2 diabetes mellitus (DM). To evaluate the possibility of correction of this metabolic shift by means of folate and vitamin B complex.

Materials and methods. 84 DM patients and 23 members of comparative group were examined. Serum homocysteine (sHcy) concentration was determined by immune-enzyme analysis. Tissue perfusion was studied via microcirculation study by laser Doppler flowmetry.

Results. The mean serum level of sHcy in DM patients was 15.9±8.2 mkM/l (8.8±1.9 mkM/l in controls, P<0,001). 74% of DM patients had serum level of sHcy over 11.0 mkM/l. No association was found between HHcy and patient’s age, sex, body mass index, remoteness of disease and the type of antidiabetic therapy as well as haemostatic, сarbohydrate and lipid metabolic parameters. Tissue perfusion in DM patients with HHcy was found to be 21% lower than that in DM patients without HHcy. After two months of folic acid intake in combination with vitamin В12 and vitamin В6 intake sHcy level decreased from 19.0±7.2 mkM/l to 12.6±5.1 mkM/l. The improvement in blood flow in the region of microcirculation and the decrease of clinical manifestations of microangiopathia were observed.

Note. Abstracts are published in author's edition

© 1996-2005, Siberian Branch of Russian Academy of Sciences, Novosibirsk
Last update: 06-Jul-2012 (11:52:05)