International Union for Circumpolar Health Ministry of Public Health and Social Development of RF Russian Academy of Medical Sciences Siberian Branch of Russian Academy of Medical Sciences Siberian Branch of Russian Academy of Sciences Medical Polar Fund “Science” The Northern Forum

Abstracts

Ecology and adaptation (medical ecology)

Introduction and aim: To study interconnection between biochemical content of bile and cholelithias prevalence in Mongoloids and Europoids from different regions of Siberia.

Study design and methods: We carried out epidemiological study of cholelithic disease in population of rural districts in Tyva, Khakasia, Evenkia and Yakutia. We performed ultrasound scanning and peroral cholecystography for 2691 Mongoloids and 2602 Europoids. In blood serum and in duodenal bile was determined the existence of lipids by biochemical tests, including the determining of bile acid spectrum – by gas-liquid chromatography in 519 Mongoloids and 404 Europoids.

Results: Cholelithic disease was diagnosed in 8,9% Europoids and in 3,1% Mongoloids of Siberia. Cholelithias was marked in native people of Tyva with the frequency of 6,5%, in the Khakass - 3,2%, in the Evens and the Evenks - 1,5%. In serum the content of lipids in Mongoloids was lower, but in bile - higher compared Europoids. In Mongoloids the content of primary cholates-chenodeoxycholic and cholic acids - was evidently higher; and the content of secondary cholates–deoxycholic and dehydrocholic acids - was lower than Europoids.

Conclusion: In Siberia cholelithiasis was marked in Mongoloids less frequently than in Europoids, which is caused by considerable differences in lipoid metabolism in these populations.

Note. Abstracts are published in author's edition

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