International Union for Circumpolar Health Ministry of Public Health and Social Development of RF Russian Academy of Medical Sciences Siberian Branch of Russian Academy of Medical Sciences Siberian Branch of Russian Academy of Sciences Medical Polar Fund “Science” The Northern Forum

Abstracts

Environmental health

The kidneys are known to be very sensitive to low temperature but the circadian rhythms of renal function in nephropathies against the background of other systems’ pathology, the problems of the time stability of the certain biorhythmic shifts under the influence of unfavorable factors affecting the organism and cold climate exposure are not yet well studied.

The aim of our investigation was to make closer definition of the changes of circadian biorhythms of the partial renal functions under the influence of malnutrition in case of chronic nephritis against the background of gastroenterological pathology. One was to establish the character, the value and the stability for a certain period of biorhythmic changes of eliminative, concentrative renal function by fixing indices after the unfavorable factor exposure. The experiments were performed every three hours for the entire circadian period and repeated in three and in five circadian periods after the fact of malnutrition have been established.

The impairment of eliminative renal function indices, time shifting of maximal peaks of the specific density and volume of the urinary excretion in comparison with the parameters determined earlier against “the favorable background” are found out to occur after the unfavorable factor exposure. If there were no regimen disturbances the following picture was established: the circadian indices of the eliminative renal function were normal, two peaks of maximal excretion were fixed during the circadian period (at 18 – 21 pm and at 6 – 9 am ), the minimum was noted at 24 pm – 6 am, the maximum of specific density was registered at 15 – 18 pm, the maximum of urinary volume was registered at 9 – 12 am. The diminishing of the circadian rate of the eliminative capacity, the appearance of new “peaks”, the shifting of the maximum peak of the volume of excreted urine ( at 21 -24 pm ) were noted three days later after the unfavorable influence. The presence of one maximum peak of excretion ( at 24 pm – 3 am ) and two minimum peaks ( at 21 – 24 pm and at 6 – 9 am ) were established five days later after the unfavorable influence. The maximum of specific density proved to deviate to later evening (at 18– 21 pm), the maximum of the excreted urine volume proved to deviate to night period (at 24 pm – 3 am).

So the findings of the research in our opinion show that the investigation of the individual biorhythms of the renal functioning in patients with nephropathies in case of different pathologies enables us to obtain more definite ideas about the character of adaptive renal biorhythms, to give information about severity of functional shifts and individual reserves of the urinary – eliminative system.

Note. Abstracts are published in author's edition

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Last update: 06-Jul-2012 (11:52:05)