International Union for Circumpolar Health Ministry of Public Health and Social Development of RF Russian Academy of Medical Sciences Siberian Branch of Russian Academy of Medical Sciences Siberian Branch of Russian Academy of Sciences Medical Polar Fund “Science” The Northern Forum

Abstracts

Ecology and adaptation (medical ecology)

Expeditionary-shift method of the labour on the north gas and oil providences is connected with all organism regulatory and homeostatic systems functioning tense. It is known, that endocrine regulation processes stable changes of the metabolism parameters can emerge as risk factors of health disorders forming. The comparative study of hormonal status in men, working in the Far North in the mode of shift labour, relatively to persons, constantly living and working in middle band of Siberia, has revealed characteristic change for the state of hypophysial- thyroid, adrenocortial and insular system functional tension. Moderate reduction of thyroxin and triiodthyronine contents, statistically significantly increase of free fractions level of these thyroid hormones, as well as thyrotropic hormone growth in blood are shown. Such changes allow to expect, that the active deioding of thyroxin not only to triiodthyronine, but also into physiologically inactive thyroid hormone metabolites (mono- and diiodthyronines) occur in peripheral tissue. Increase of the free thyroid hormones content indicates the reinforcement of their contribution to metabolism regulation in the organism of shiftworkers, residing in the Far North ecological terms at an examinations period. The adrenocortical hormones content evaluation has shown a reduction of the cortisol level and increasing of aldosteron in blood, that points to the exhaustion of adrenal cortex adaptive reserves. Glucose, cholesterol, triglyceride and beta-lipoprodeide content is shown to increase in shiftworker blood while north experience grows; herewith a number of statistically significant correlation links between biochemical and hormonal factors falls and those of studied parameters of hormonal status increases.

The endocrine system tense operation and gradual reduction of its reserves with residency duration increase in the North is greatly reflected on the picture of shiftworkers’ health and their working capability. The reliability reduction is monitored to depend on cortisol lowering; the number of cardiovascular and respiratory disadaptive frustrations is shown to increase under endocrine system function tension while north experience is grown. The increased levels of insulin and aldosteron in blood occurred to be prognostically unfavourable risk factors for arterial hypertension forming. Straight dependence between the aldosteron content in blood and disadaptive arterial hypertension level in persons of shift labour in the Far North is checked.

Note. Abstracts are published in author's edition

© 1996-2005, Siberian Branch of Russian Academy of Sciences, Novosibirsk
Last update: 06-Jul-2012 (11:52:05)