International Union for Circumpolar Health Ministry of Public Health and Social Development of RF Russian Academy of Medical Sciences Siberian Branch of Russian Academy of Medical Sciences Siberian Branch of Russian Academy of Sciences Medical Polar Fund “Science” The Northern Forum

Abstracts

Ecology and adaptation (medical ecology)

There have examined 90 practically healthy male-shift-workers 21-58 aged and 21-60 aged (average age 41,4± 1,4 and 48,6±1,3 ), worked for a long period of time in the North and working on a shift at the enterprises of JS “Yamburggasdobycha” at the moment of examination.

It was revealed a high content of glycosaminoglycans (GAG) in blood serum (2,20±0,12 mmol/l), accumulation of LPO products (3,45±0,18 nmol MDA/ml)on the background of decreased glutationreductase activity (0,38±0,04 mkmol/l hour). Level of total cholesterol was increased at standard content of HDL (6,1+0,2).

Negative features between GAG content in blood and duration of shift labor testified both about disorder of exchange activity and deep structural changes in connective tissue of shift-workers. The feature between MDA content in blood and duration of shift labor possessed a phase character. First at increased duration of shift labor, content of MDA in blood as well as activity of peroxidative processes decreased. It reflected the state of tension of organism regulatory and homeostatic systems. Two types of reactions have been revealed. An increased duration of working resulted in a decreased peroxidative processes activity or it remained without changes. (1st type). Positive correlation between peroxidative processes activity and increased tissue destruction as well as duration of shift labor were typical for 2nd type of reaction.

Thus, definition of MDA in blood of shift-workers, reflecting intensity of the northern oxidative stress can be considered as an important prognostic criterion, showing the increase of destruction in connective tissue followed by development of disadaptative (prepathological) states, manifesting in premature organism aging. It can be concluded that definition of GAG and MDA in blood is one of the significant criteria, reflecting adaptative tension and premature aging of shift-workers.

Note. Abstracts are published in author's edition

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Last update: 06-Jul-2012 (11:52:05)