International Union for Circumpolar Health Ministry of Public Health and Social Development of RF Russian Academy of Medical Sciences Siberian Branch of Russian Academy of Medical Sciences Siberian Branch of Russian Academy of Sciences Medical Polar Fund “Science” The Northern Forum

Abstracts

Genetics, demography, anthropology

Mitochondrial DNA (mtDNA) polymorphism is widely used in human population genetics and evolutionary genetics. Many Siberian ethnic groups were studied in respect of mtDNA polymorphism. However, in most cases the data were obtained on “combined” samples from several populations which not always sufficiently characterize the ethnic group in common. The aim oh this study was to assess intraethnic and interethnic differentiation of mtDNA polymorphism in Turkic-speaking peoples of Siberia. Three most numerous peoples were studied: Tuvinians (N=451), Altaians (N=131) and Yakuts (N=120). For each ethnic group, data were obtained from several populations (three populations for Tuvinians and Altaians, and two populations of Yakuts), thus allowing estimation of differentiation of their mitochondrial gene pool. The study of mtDNA polymorphism was carried out by sequencing of HVSI and restriction analysis. 177 different HVSI haplotypes were revealed in total which represent hagplogroups A, B, C, D, F, G, H, I, J, M7, M9, N9, T, U, HV, W, X, Y, Z. The most abundant were C and D haplogroups. Most of the haplotypes were registered in one or two samples, for instance only 16 of 90 haplotypes found in Tuvinians were present in all three Tuvinian samples. However, AMOVA analysis carried out in Arlequin package has shown low level of intraethnic differentiation, more marked for Altaians. The results point to relative isolation and differentiation of mitochondrial gene pools of Siberian Turkic-speaking peoples, and existence of both common and ethnic-specific components in their population histories.

The study was supported by RFBR grant no. 04-04-48792.

Note. Abstracts are published in author's edition

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