International Union for Circumpolar Health Ministry of Public Health and Social Development of RF Russian Academy of Medical Sciences Siberian Branch of Russian Academy of Medical Sciences Siberian Branch of Russian Academy of Sciences Medical Polar Fund “Science” The Northern Forum

Abstracts

Cardiovascular diseases

Stroke is the third leading cause of death in the United States. Stroke is characterized by a cerebral vascular accident (CVA) resulting in a loss of blood flow to the brain. The focus of this laboratory is to investigate the cellular and molecular mechanisms involved in the pathophysiology of atherosclerosis and stroke. One specific aim is to develop neuroprotective treatments following ischemic stroke. Published data from our laboratory, using a rat middle cerebral artery occlusion (MCAO) stroke model, demonstrates that neuregulin-1 (NRG-1) protects neuronal cells from irreversible damage following acute stroke. The purported neuroprotective mechanism of NRG occurs through cell signaling pathways by regulation of E26 transformation-specific (Ets-1) and other transcriptional elements in the promoter region of genes associated with apoptosis induced by ischemic stroke. The central hypothesis of this project is that the growth factor NRG-1 activates the Ets repressor factor (ERF) to protect neuronal cells following ischemia. To investigate this hypothesis we employed the following specific aims: to determine the expression of ERF under ischemic conditions in vivo and in vitro and to determine the role of ERF in the NRG-1 protection of neuronal cells under ischemic conditions. © 2005 Morehouse School of Medicine Neuroscience Institute

Note. Abstracts are published in author's edition

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Last update: 06-Jul-2012 (11:52:05)