International Union for Circumpolar Health Ministry of Public Health and Social Development of RF Russian Academy of Medical Sciences Siberian Branch of Russian Academy of Medical Sciences Siberian Branch of Russian Academy of Sciences Medical Polar Fund “Science” The Northern Forum

Abstracts

Environmental health

Aim. To study interconnection of Helicobacter pylori (НР) Cag A strains and ulcer diseases in the Mongoloids and the Europoids in different regions of Siberia.

Methods. We carried out large scale epidemiological research in Tyva, Khakassia, Evenkia, Yakutia and Eastern Siberia middle latitudes. HP was determined by serological, morphological (Gimza colouring) and urease techniques, by polymer- chain-reaction method in 3494 patients (1365 Mongoloid, 2129 Europoid). IgG Cag A was diagnosed by immune-ferment-analysis technique in blood serum in 562 subjects in Khakassia and 493 in Evenkia. Esophagofibregastroduodenoscopy was carried out for 5215 subjects (2701 Europoid and 2514 Mongoloid).

Results. Total prevalence of ulcer disease in the Europoid made 8.4%, in the Mongoloid 3.5%. HP prevalence made in the Mongoloid 91.3%, in the Europoid 89.6%. Hp Cag A prevalence in the Mongoloid made 39.4%, in the Europoid 60.3% (р<0.001). In all the regions HP dissemination density in mucous layer of stomach antral part was higher in the Europoid than in the Mongoloid 1.5 to 3 times. HP strains were associated with ulcer disease in the Mongoloid, but not in the Europoid of Siberia.

Conclusion. HP Cag A association with ulcer diseases is opposite to Cag A prevalence index in target population.

Note. Abstracts are published in author's edition

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Last update: 06-Jul-2012 (11:52:05)