International Union for Circumpolar Health Ministry of Public Health and Social Development of RF Russian Academy of Medical Sciences Siberian Branch of Russian Academy of Medical Sciences Siberian Branch of Russian Academy of Sciences Medical Polar Fund “Science” The Northern Forum

Abstracts

Ethnic peculiarities of the North native inhabitants health

Helicobacter pylori showed a great genetic diversity and can be divided into a number of populations and subpopulations with distinct geographical distributions. About half of strains possess CagA protein that is considered to be a major marker of virulence and associated with peptic ulcer and gastric malignancies.

The aim of the present study was to evaluate the seroprevalence of CagA positivity among different ethnic groups in Siberia.

Random samples of the general population were examined in Novosibirsk (887 Caucasians) and among Asian natives in various regions of Siberia and Far East: Nenets (44), Touvinians (111), Koryaks (151), Chukchi (57). Sera were tested for antibodies against CagA protein of Helicobacter pylori with ELISA (“HelicoBest”, Vector-Best, Russia).

The prevalence of CagA positivity was 1.6 times lower in white children in Novosibirsk comparing to native children in other regions of Russia. Among children aged 5-10 years, 28.0% were positive in Novosibirsk and 45.0% in Touva. Among children aged 11-20 years, the corresponding figures were 35.1% and 57.1% respectively. Among adults, similar figures were found in all ethnic groups (46.9%-55.5%) except Touva (71.4%).

In conclusion, CagA seropositivity is uniformly high among Russian population despite different ethnic and geographic background. In Novosibirsk, lower prevalence in children may reflect higher socioeconomic conditions compared to rural regions.

Note. Abstracts are published in author's edition

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Last update: 06-Jul-2012 (11:52:05)