International Union for Circumpolar Health Ministry of Public Health and Social Development of RF Russian Academy of Medical Sciences Siberian Branch of Russian Academy of Medical Sciences Siberian Branch of Russian Academy of Sciences Medical Polar Fund “Science” The Northern Forum

Abstracts

Environmental health

One of the most widespread cardiovascular diseases in northern and temperate latitudes is the arterial hypertension. At that in polar areas younger people suffer from hypertension. So, it is shown, that in Norilsk and Chukotka 13-18 % of north-erners develop arterial hypertension (АG) at the age of 30-39. The AG pathogenesis can be caused by cardiovascular regula-tion or kidney function disturbances. Searching of early AG diagnostics methods on the basis of functional loads seems inter-esting and important in practical relation.

The purpose of the work is to estimate interrelations between hemodynamics and kidney function parameters in rest and after two types of functional loads: water and hypoxic.

37 young men of 18-28 were examined. Cardiovascular system and kidney function (diuresis, sodium excretion, potas-sium and creatinine excretion, and urine osmotic agents concentration) reaction to water load (10 ml for 1 kg of body weight), and also to hypoxia (inhalation of a 10 % oxygen air mix for 10 minutes) were investigated. In all of the subjects investigated by a venous occlusion plethysmography method (PERIQANT 3500, Germany) arterial blood flow, venous reserve, venous out-flow and reactive hyperemia were measured. Arterial pressure was simultaneously measured by automatic registrar MT-5 (USA). Registration of specified parameters was carried out before water intake and every 60, 90, 120 minutes after water and also hypoxic loads. Urine samples were taken before water ingestion and every 30 minutes within 2 hours.

As a result of statistical processing of the material we have received a confirmation that after the water loads cardiovas-cular system and kidneys reactions increase. If the background arterial muscular blood flow made 1,78±0,52 ml / 100 ml∙min, then after the water load it became increased up to 1,96±0,82 ml / 100 ml∙min. Initial diuresis made 1,07±0,5ml/min•1.73m²; sodium excretion - 197,6±13,6mkM/min•1.73m²; potassium excretion -63,5±5,6mkM/min∙1.73m². Diuresis after water load 10,36±4,5ml/min•1.73m²; sodium excretion - 402,4±23,9 mkM/min•1.73m²; potassium excretion - 135,9±17,3 mkM/min•1.73m².

In all the examined subjects we observed correlative interrelations between all parameters of cardiovascular system and kidneys. The strongest interrelations are observed between diuresis, sodium excretion and arterial muscular blood flow (r=0.667) and (r=0.725) correspondingly, and also between sodium excretion and venous reserve (r =-0,51), urine osmotic agents concentration and arterial muscular blood flow (г=0,6). After the hypoxic load - between sodium excretion and arterial blood flow (r=0,646) and venous reserve (r=0,538), correspondingly, and between potassium excretion and reactive hyperemia (r =0,59) at p < 0,05.

Note. Abstracts are published in author's edition

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Last update: 06-Jul-2012 (11:52:05)