International Union for Circumpolar Health Ministry of Public Health and Social Development of RF Russian Academy of Medical Sciences Siberian Branch of Russian Academy of Medical Sciences Siberian Branch of Russian Academy of Sciences Medical Polar Fund “Science” The Northern Forum

Abstracts

Ethnic peculiarities of the North native inhabitants health

Morbidity rate of Diabetes Mellitus (DM) depends on ethnicity.

Purpose: to study state of lipid peroxidation (POL) and antioxidant system (AOS), association between DM 1 type (DM1) and mononucleotide polymorphism of (SNP) gene CTLA4 49A/G in patients with DM1 of Buryat population.

We examined 27 patients with DM 1 (mean age 32,7±2.3 years) of Russian population and 38 patients with DM 1 of analogous age of Buryat population. Genetic research was done in 74 patients with DM1 of Buryat population aged 1 to 40 yrs.

There has been found activation of POL in patients with DM 1 in Russian population with reliable accumulation of peroxidation products against the patients with DM 1 in Buryat population (p<0.05). In patients with DM 1 in Russian population there has been marked reliable elevation of α-tocopherol concentration for 24% and in patients of Buryat population with DM 1 type – antioxidant activity (AOA) increased for 30%. Distribution of CTLA4 genotypes in patients with DM1 of Buryat population and in the control group of Buryats: in the group of patients with DM1 the frequency of genotype GG constituted 51.4% and in the control group – 42.6% (p>0.05). Amount and frequency of alleles and genotypes SNP 49AG were: in patients with DM1 frequency of allele A – 27.7% and allele G – 72.3%; frequency of genotype- AA – 6.76%, AG – 41.9%, and GG – 51.4%; frequency of phenotype AA+AG – 48.65% and GG+AG – 93.24%; in the control group – frequency of allele A – 36.06% and allele G – 63.93%; frequency of genotype AA – 14.75%, AG – 42.62%, and GG – 42.62%; %; frequency of phenotype AA+AG – 57.37% and GG+AG – 85.24%.

Thus, POL and AOP state in patients with DM of Russian and Buryat population differ. Associations of SNP 49A/G of gene CTLA4 with propensity for DM1 in Buryat population was not detected.

Note. Abstracts are published in author's edition

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Last update: 06-Jul-2012 (11:52:05)