International Union for Circumpolar Health Ministry of Public Health and Social Development of RF Russian Academy of Medical Sciences Siberian Branch of Russian Academy of Medical Sciences Siberian Branch of Russian Academy of Sciences Medical Polar Fund “Science” The Northern Forum

Abstracts

Ecology and adaptation (medical ecology)

Changes in the regulatory and homeostatic systems, appearing as a result of combined influences of the northern natural and industrial environment extreme factors on a human organism, precede a pathology formation, define its nature and specificity; such influences being of greater value length and nature (constant or fractional). Studies of the hormonal regulation particularities of metabolism processes in persons, living constantly or in the mode of shift work in the extreme northern conditions, are necessary to reveal the mechanisms of disadaptation and pathological conditions formation, forecasting of health and working capacity, and live improving arrangement design. The comparative analysis of the hormonal and biochemical parameters in men aged 23 -65, moved for constant residency and work on the mine in the Mirny city of the Sakha Republic (Yakutia) or working in the mode of shift labour on gas providences of "Yamburggasdobycha" company was held. Evaluation of the functional conditions of the hypophysis-thyroid system has showed, that at the initial period up to 5 years of the north experience the thyrotropic hormone, general thyroid hormones and free thyroxin levels have been nearly the same, but the most functionally active hormone triiodothyronine content has been statistically significant above in inhabitants of Mirny. While the north experience increasing, at a period from 5 to 15 years, the changes of thyrotropic hormone content have the opposite directed nature: in Mirny inhabitants this factor falls, but among shiftworkers it grows, moreover, free triiodthyronine content staying lower, reflecting the insufficiency of thyroid hormones at peripheries. The difference in the contents of thyrotropic hormone is saved, herewith in shiftworkers the content of blood free triiodthyronine increases at the north experience more than 15 years. The content of the main adaptive hormone – cortisol in blood, as well as insulin, in Mirny inhabitants is not changed while north experience increasing, and stay within average values, characteristic for inhabitants of the middle band of Siberia. The cortisol content is already lower at a first period in shiftworkers then among Mirny inhabitants, and tend to fall at north experience growth, but the insulin level is above and tend to increase. The contents of glucose, cholesterol and triglycerides in blood are changed insignificantly while increasing a north experience in Mirny inhabitants, but them constantly growing beside shiftworkers. Thereby, the changes of hormonal and biochemical parameters under north experience increasing in persons, working in the mode of shift labour on the North, are vastly greater denominated, than among Mirny inhabitants, and reflect a pronounced accumulation of negative signs of health disorders forming.

Note. Abstracts are published in author's edition

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Last update: 06-Jul-2012 (11:52:05)