Abstracts

Human Genome Diversity

The glutation S-transferase (GST) are widely expressed in mammalian tissues and involved in phase II detoxification reactions. The GST form a supergene family consisting of four distinct families, named alpha (GSTA), mu (GSTM), theta (GSTT) and pi (GSTP). Several of GST is polymorphic in humans. Among the GST genes we examined GSTT1 and GSTM1 polymorphism in some populations from Russian Federation: Russians from Holmogory and Oshevensk (Archangelsk region) and three populations with different level of Mongoloid component: Chant, Kalmyk and Buryat.

We observed that frequency of GSTM1 null genotype is significantly higher in Chant, Kalmyk and Buryat than in Russians from Archangelsk region. For GSTT1 gene null genotype frequency was statistically higher for Kalmyk and Buryat (p=0,03), but in Chant it was similar as in Russians from Archangelsk region. Total frequency GSTM1 (0/0), GSTT1 (0/0) for Kalmyk and Buryat was 18% and 15 % respectively, while in other populations it was not bigger than 5%. Comparing Mongoloid populations with Russians using c2-criterium and G-statistic one can see that Kalmyk and Buryat populations mostly vary from Russians populations, and differences between Chant and Russians are less expressed. We can note that population differences are more conditioned by difference in GSTМ1 genotype frequency. Gene GSTТ1 has less marked divergence in populations, and these gene frequencies less vary for Oshevensk, Holmogory and Chant populations.

Note. Abstracts are published in author's edition

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