Abstracts

Human Genome Diversity

The polymorphisms of five DNA-loci ﷓ TaqI A and NcoI restriction polymorphisms of a D2 dopamine receptor gene, VNTR- polymorphism of a dopamine transporter gene, MspI restriction polymorphism of a 2A serotonin receptor gene and VNTR- polymorphism of a serotonin transporter gene are investigated in eight populations of the Volgo-Ural region (Bashkirs, Tatars, Chuvashes, Mari, Mordvinians, Udmurts, Komi, Russian of Bashkortostan). The genotype and allele frequencies of five loci of neuromediator system genes are determined. The genotype frequencies of studied loci didn’t deviate from Hardy-Weinberg equilibrium for all populations. A significant interpopulational distinctions in polymorphisms of investigated loci are found. We carried out a rating of genetic similarity of the Volgo-Ural region populations in the terms of genetic distances designed on allele frequencies of five polymorphic DNA-loci, and the neighbour tree was constructed. Close have appeared the Udmurts and Komi populations concerning to Finno-Ugric branch of the Ural language family. The population of Chuvashes adjoins to them, however the genetic distance between it and both populations of the Udmurts and Komi is much more than distance between these Finno-Ugric populations (0,016 in comparison with 0,004). Other populations have formed the second branch, which has been removed enough from first (0,026). It is important to note, that all populations forming the second branch, are located closely to each other enough. The genetic distances between them change from 0,007 up to 0,015. Pays on itself attention affinity of an arrangement of the Russians and Tatars populations (0,007), concerning to different ethnic groups - according to a East-Slavic branch of the Indo-European language family and a Turkic branch of the Altay language family. Such arrangement on the neighbour tree of the Russians and Tatars populations does not correspond to their historical, linguistic and antropological classification. It is possible, that the considered systems do not belong to selectively neutral and the attributes, controllable by these genes, can be subject to pressure of the regular factors. Thus, the results of a rating of genetic distances between the investigated populations on five DNA loci of the neuromediator system as a whole will be coordinated to the literary data on another loci of a nuclear genome and testify that the populations of the Volgo-Ural region have enough complex genetic structure. It is connected, apparently, to a different history of region settling, social orientation, economic-cultural structure of these people populations and other factors.

Note. Abstracts are published in author's edition

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