Abstracts

Human Genome Diversity

A lot of studies in gene fund diversity is carrying out due to creation of the new branch of science - ethnogenomics. Minisatellites are autosomal DNA markers with high degree of individual diversity. Because of these markers possess remarkable lineage peculiarities they used in evolutionary genomics, forensic science and ecology monitoring of mutation appeared upon ionizing radiation action.

Analysis of D1S80 (pMCT118) and apolipoprotein B gene minisatellites have been carried out in East Slavs, Kalmyks and Jakut populations. Allele distributions of minisatellites was found to be similar between East Slavs and Europeans. Allele distribution of Jakut differ from East Slavs statistically but simulated with other Orientals.

The method of computer gene geography was used to prepare a set of geographic variability maps for all alleles of minisatellites. The maps were constructed using reliability theory to provide a statistical base of simulate mapping. First principal component maps of both minisatellite reveal maximun variability in Ural mountain area, implying most impotant role of the region in present gene fund forming.

Bibliography

1.Dubrova Y.E., Plumb M., Brown J., Jeffreys A.J. Radiation-induced germline instability at minisatellite loci. // Int. J. Radiat. Biol. 1998, v.74, N6, p.689-696.

2.Limborska S.A., Balanovskaya E.V., Khusnutdinova E.K. Ethnogenomics and gene geography of East European region. // М: Nauka, 2001, in press.

Note. Abstracts are published in author's edition

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