Тезисы докладов

Изменчивость генома человека

The phylogenetic backbone of east Asian mtDNA tree is discussed in phylogeographic context. Combined analysis of control and coding region variation shows that that the east Asian mtDNA pool is regionally specific and completely covered by the two haplogroups M and N. The phylogenetic partitioning based on complete mtDNA sequences corroborates existing RFLP based classification of Asian mtDNA types and supports the distinction between northern and southern populations. We describe new haplogroups M7, M8, N9, and R9 and demonstrate by way of example that subdividing the hierarchy of the mtDNA tree aids in recognising further the settlement processes of any particular region in appropriate time scale. This is illustrated by the characteristically southern distribution of haplogroup M7 in eastern Asia, whereas its daughter-groups, M7a and M7b2 are specific for Japanese and Korean populations. Haplogroup CZ is widely spread in eastern Eurasia and occurs most frequently in Siberian populations. Haplogroup C is also present as one of the five basic mtDNA haplogroups in Native Americans. Phylogeographic analysis of Asian C and Z HVS-I haplotypes suggests their possible split in northern China or southern Siberia at time depth 30,000 - 45,000 years ago. Low haplotype diversity of C and Z among Native Siberian populations is consistent with holocene expansion(s) from a number of regionally but not linguistically specific founder lineages. Higher diversity and existence of multiple sister-founders is identified in Inner Asia. Both haplogroups have, together and separately, been involved also in migrations directed possibly from Central Asia to western Asia and to southern China.

Примечание. Тезисы докладов публикуются в авторской редакции

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