Сибирское отделение РАН 
Институт цитологии и генетики

Первое международное рабочее совещание "Биоразнообразие и динамика экосистем Северной Евразии: информационные технологии и моделирование" (WITA-2001)

9-14 июля 2001 года, Новосибирск, Россия

Тезисы докладов

Изменчивость генома человека

mtDNA lineages from European part of Russia: a clue to reveal prehistoric demographic and migration processes

Orekhov V.A.1, Tambets K.2 , Rootsi S.2, Injutin A.1, Adojaan M.2, Kozhekbaeva J.1, Bermisheva M.3, Viktorova T.3, Gusar V.4, Grechanina E.4, Kivisild T.2, Parik J.2, Ivanov P.5, Yankovsky N.K.1, Khusnutdinova E.3, Villems R.2

1 - Vavilov Institute of General Genetics RAN,
Moscow,
Russia; 2 - Dept. Evolutionary Biology,
Tartu University,
Tartu,
Estonia; 3 - Institute of Biochemistry and Genetics,
USC RAN,
Ufa,
Russia; 4 - Center of the Clinical Genetic and Prenatal Diagnostics,
Kharkov,
Ukraine; 5 - Engelhardt Institute of Molecular Biology RAN,
Moscow,
Russia.

High resolution analysis of maternal lineages in Russians and Ukrainians was made with a standard aproach: sequencing of HVSI and RFLP analysis of haplogroup specific mtDNA polymorphisms. Phylogenetic relations of revealed haplotypes was described with a high-resolution median network reconstruction of the most parsimonious tree for 300 Russians and Ukrainians. Analisys was performed on a base of database which includes data on more then 13 000 individuals. A vast majority of revealed haplotypes (>95%) belongs to well described European haplogroups (H, HV, I, J, T, U, V, W, X, N1). Besides this Asian-specific haplogroup M was reviled in both of studied populations (with frequencies 1% in Ukrainians and 2% in Russians). On the level of more detailed phylogenetic analysis both features of similarity and difference of studied populations were revealed. For instance Russians showed high frequency of haplogroup U4, comparing to Ukrainians and other Slavs. This haplogroup is most frequent in Finno-Ugric populations of Baltic and Volga-Ural region. High frequency of U4 together with frequencies of some small clusters can provide information on quantitative contribution of Finno-Ugric populations in mtDNA gene pool of Russians. The lineage sharing analysis revealed comparatively high percentage of Finno-Ugric specific mtDNA lineages in Russians. In spite of language similarity there are some differences between Russians and Ukrainians even in frequencies of large haplogroups. For instance haplogroup T in Russians has a frequency (10%) which is typical for most European populations, while Ukrainians have one of the lowest frequency of T in Europe (3%). The same frequency of T have Poles, who are neighbouring with Ukrainians. So, in whole Russians and Ukrainians have typical for Europeans patterns of mtDNA diversity, however we found features, which are more correlate with geographic position then with language affinity.

Примечание. Тезисы докладов публикуются в авторской редакции

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