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Первое пленарное заседание

CHIF is a short transmembrane protein that is specifically expressed in the basolateral membrane of kidney collecting duct and distal colon surface cells. It is a member of the FXYD family with includes the gamma subunit of the Na/K ATPase, phospholemman and Mat-8. Work in our laboratory had demonstrated that CHIF is independently regulated by Na deprivation through an increase in plasma aldosterone. Independently it is up-regulated by K-loading independent of aldosterone. Studies in transfected cells have established that CHIF , as well as other FXYD proteins, physically interact with the alpha subunit of the Na/K ATPase and alter the pump kinetics. The physiological role of CHIF in kidney function was further elucidated by the phenotypic analysis of CHIF knockout mice. Under a high K diet the -/- mice exhibited higher urine volume and an increased glomerular filtration rate. Treating K loaded mice with furosemide results in lethality in -/- but not in +/+ mice. The results are consistent with the model that CHIF is a kidney specific regulator of the Na/K ATPase whose role is to increase Na absorption and K secretion under limiting intracellular Na activities.

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