International Union for Circumpolar Health Ministry of Public Health and Social Development of RF Russian Academy of Medical Sciences Siberian Branch of Russian Academy of Medical Sciences Siberian Branch of Russian Academy of Sciences Medical Polar Fund “Science” The Northern Forum

Abstracts

Environmental health

The new approach in physiology and medicine based on the analysis of slow oscillatory processes in a human organism is a good outlook for an estimation of adaptation processes to adverse ecological environment and promotes new approaches in diagnostics and treatment of neurosomatic pathologies, including an arterial hypertension (Fleishman A.N., 1999; Nikolaev Y.А. et al., 2001; Filimonov S.N., 2002; etc.). Slow heart rate fluctuations give an integrated estimation of metabolic and neuroautonomic regulations and provide prognosis. The purpose of this work is to develop a new approach in physiology and medicine for the adaptation processes estimation and pathogenetic therapy of neurosomatic disorders.

Material and methods. The classification of heart rate variability (HRV) and slow hemodynamic fluctuations (SHF) phenomena has been developed on the basis of the clinical and physiological analysis of 15 thousand patients with various psychosomatic pathologies (arterial hypertension, neuroendocrinal disorder, central nervous system diseases: hypertensive encephalopathy, neuroses, neuroautonomic attacks, etc.) and also healthy persons aged 14-75 ys. Three classifications of HRV have been developed: depending on power, neuroautonomic spectral structure and nonlinear parameters (Fleishman A.N., 1999, 2002). HRV classification became a basis of an estimation of organism adaptation to adverse environment conditions, both climatic and industrial.

Initial data registration and analysis were carried out using hardware and software developed in our country and abroad. The software for HRV analysis included three types of mathematical analysis (statistical time analysis, spectral Fourier- and Wavelet analyses), and also various parameters of nonlinear dynamics (phase portraits (PPs) of HRV in two- and three-dimensional space, detrended fluctuation analysis (DFA), approximated entropy). The procedure of data registration and analysis are published (Fleishman A.N., 1999, 2001, 2005).

Results. 1. HRV adaptation processes are registered in loading tests dynamics or in long-term changes of HRV structure, in particular at the transient from normal variability to hyperadaptive states and hyperadaptive reactions, from parameters of HRV energy deficient changes and metabolic processes to cyclic HRV PPs, and also at the transient from simplified cyclic to cyclic chaotic and chaotic PPs, from decreased parameters of approximated entropy to normal or increased ones. The dynamics of neuroautonomic and spectral HRV parameters also change its structure. In particular the central frequency of 10-second rhythms moving to low or high frequency ranges can testify adaptation or disadaptation processes. 2. The differentiated therapy of arterial hypertension at heart rate power and structure changes is based on the following regularities: it is recommended to use beta-adrenal-blockers combined with medicines intensifying metabolic processes (alpha-thioctic acid, cytochromes, coenzymes, etc.) at the obvious decrease of HRV power in total or high-frequency part of a spectrum; calcium blockers combined with sedative therapy at the hyperadaptive processes with cerebral neuroautonomic dysfunction signs, 30-40-second rhythms increase, bradycardia; ACE (angiotensin converting enzyme) inhibitors at normal HRV power values.

Conclusion. The new approach in physiology and medicine demands wide approbation in northern regions of our country taking into consideration long-term adaptation processes for inhabitants of northern regions, gender and age peculiarities.

Note. Abstracts are published in author's edition

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Last update: 06-Jul-2012 (11:52:05)