International Union for Circumpolar Health Ministry of Public Health and Social Development of RF Russian Academy of Medical Sciences Siberian Branch of Russian Academy of Medical Sciences Siberian Branch of Russian Academy of Sciences Medical Polar Fund “Science” The Northern Forum

Abstracts

Genetics, demography, anthropology

The composition and frequencies of Y chromosome haplogroups were revealed in native populations of Siberia, Eastern Europe and Central Asia. 25 haplogroups were observed, but frequency of only 7 of them (N3a, R1a1, Q*, C3*, N2, C3c and O3) were higher than 3 percent. In sum these 7 haplogroups comprise 86% of Y-chromosomal gene pool in North Eurasian population.The proportion of inter-population differences (Fst) in the total genetic variability of region’s population according to the analysis of molecular variance (AMOVA) data is 19.04%. Inter-individual differences within populations account for the rest of total genetic diversity (81%). Analysis of genetic diversity within geographical groups reveales the high level of genetic differentiation in Eastern and Western Siberia. Male lineages in population North-East Asia and Central Asia are less differentiated, but the value of genetic differentiation’ coefficient is still relatively high. Slavic population of Eastern Europe in contrast to other regions investigated are characterized by the uniformity of male gene pool. Based on analysis of microsatellite haplotypes within main Y-chromosomal haplogroups, molecular diversity within monophyletic lineages were calculated and phylogenetic trees for most common haplogroups (C3, C3c, C3*, N2, N3a, Q*, R1a1, R1b) were reconstructed. Western-Eurasian lineages (R1a1, R1b) are characterized by the maximal diversity in Caucasoid populations. Among Siberian ethnic groups, the highest diversity of these lineages was found in Altay-Sayan populations, which probably reflects the presence of substantial amount of ancient Neolithic Caucasoid components in their gene pool. Eastern-Eurasian lineages (C3c, C3, C3*, O, Q) have the high level of diversity of microsatellite haplotypes in populations of Eastern Siberia and North-East Asia, but their founder haplotypes and higher genetic diversity associated with them were found in populations of South-East Asia. N3a lineage is characterized by maximal frequency and maximal diversity of microsatellite haplotypes in North Eurasia. In particular, founder haplotype has high frequency in Altay-Sayan Turkic populations and in Finno-Ugric ethnic groups. Phylogeographic analysis for main Y-chromosomal North Eurasian lineages was performed including mapping of haplogroup frequency and molecular diversity. Data of phylogeographic analysis were used to reconstruct the distribution of Y-chromosomal lineages in connection to the peopling of North Eurasia.

Note. Abstracts are published in author's edition

© 1996-2005, Siberian Branch of Russian Academy of Sciences, Novosibirsk
Last update: 06-Jul-2012 (11:52:05)