International Union for Circumpolar Health Ministry of Public Health and Social Development of RF Russian Academy of Medical Sciences Siberian Branch of Russian Academy of Medical Sciences Siberian Branch of Russian Academy of Sciences Medical Polar Fund “Science” The Northern Forum

Abstracts

Cardiovascular diseases

OBJECTIVE: We aimed to investigate the predictors of cardiovascular (CVD) incidence and mortality in Siberian population during a period of global social changes.

METHODS: The baseline risk factors were monitored in Novosibirsk population samples in the frame of the WHO MONICA project. The cohorts comprised of 4,897 men and 3,268 women (aged 25-64) were followed-up on the average 9.5 and 8.4 years, respectively. Acute myocardial infarction (MI), acute stroke (STR) events and CVD deaths were registered as end points.

RESULTS: The hypertension independently increased the 9-year relative risk (RR) of CHD mortality and CVD mortality more than twice. RR for STR incidence in hypertensives was of 2.9 (95%CI: 1.4-5.8) for men and 4.6 (95%CI: 1.8-11.7) for women. High total cholesterol, high triglycerides and low HDL cholesterol levels were independently associated with MI incidence in men and did not increase the risk of STR. The risk of MI was 2.5 times higher, and risk of CVD death – 2.8 times higher in smoking men. The obesity was associated with CVD risk only before adjusting for covariates. The risk of fatal CVD was elevated two times in binge alcohol drinking and was associated with low education and unmarried status.

CONCLUSION: The findings confirm that conventional factors are powerful predictors of CVD outcomes in Siberian population. The rapid mortality changes since transition suppose the interactive effects between conventional and other potential risk factors focusing on social determinants.

Note. Abstracts are published in author's edition

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Last update: 06-Jul-2012 (11:52:05)