International Union for Circumpolar Health Ministry of Public Health and Social Development of RF Russian Academy of Medical Sciences Siberian Branch of Russian Academy of Medical Sciences Siberian Branch of Russian Academy of Sciences Medical Polar Fund “Science” The Northern Forum

Abstracts

Environmental health

In the frame of the cross-sectional epidemiological study WHO “MONICA” of the open population residing in Novosibirsk, carried out by state of IIM RAMS (Program Director – acad. RAMS Nikitin Yu.P., Principal Investigator – prof. Maliyutina S.K.), was proved, that GSD met more frequently among persons with lipid metabolism disorders. In patients with GSD high Lipoprotein(a) (Lp(a)) levels (>30 mg/dl) in blood serum met significantly more frequently, than in persons without GSD. Elevated Lp(a) levels associated with GSD independently from basic risk factors of GSD. Blood serum Lp(a) levels positively correlated (r=+0,34, p<0,05) with cholesterol bile concentration in women with cholesterol GSD. Most “atherogenious” apolipoprotein(a) isoforms В, S2 in patients with GSD met significantly more frequently, than in persons without GSD; bile lithogenicity was highest if patients with cholesterol GSD at presence of these apo(a) isoforms. Such “lipid-associated” diseases as Coronary Heart Disease, Arterial Hypertension and Diabetes Mellitus met 2-3-fold frequently in women with GSD (p<0,05).

In the clinic research in women with verified cholesterol GSD was proved that total cholesterol blood serum levels positively correlated (r=+0,53, p<0,05) with cholesterol and common bile acids content (r=+0,45, p<0,05) in bile. A polymorphism of the APOE locus has been identified as a risk factor for cholesterol gallstones. In epidemiological study APOE polymorphism did not differ in persons with and without gallstones, but in women with cholesterol GSD the E4 genotype was associated with significant increased cholesterol content in bile.

Among the teenagers of 14-17 years surveyed within the framework of epidemiological research (Principal Investigator – candidate of medical sciences Denisova D.V.) in children of parents with GSD was proved that gallbladder hypokinesis (GH) met significantly more frequently, than in hereditary stone-free teenagers. In this group of teenagers with GH level of HDL was significantly lower than in teenagers with normal gallbladder contraction.

In conclusion, our 10-year experience prove the important role of the lipid metabolism disorders in the gallstone pathogenesis.

Note. Abstracts are published in author's edition

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Last update: 06-Jul-2012 (11:52:05)